Phase I Trial of Methotrexate-Albumin in a Weekly Intravenous Bolus Regimen in Cancer Patients

Patients’ characteristics

Two patients did not want to participate in the study after detailed information. Six healthy individuals and six subjects with arthralgia without any sign of an inflammatory rheumatic disease served as the control group. and after two or four courses in two patients treated with 60 mg/m 2 . One female patient showed signs of skin toxicity with slight papulosquamous lesions on both forearms and legs (grade 3) after the first administration of 60 mg/m 2 .

Fluorescence optical imaging in pediatric patients with inflammatory and non-inflammatory joint diseases: a comparative study with ultrasonography

Symptom scales that have historically been employed to assess response to treatment in GORD clinical trials do not typically account for the heterogeneous, episodic nature of GORD and the poor correlation between patients’ and physicians’ assessment of symptoms. The ReQuest questionnaire permits self-assessment of changes on a broad range of GORD-related symptoms on a daily basis and in combination with the Los Angeles (LA)-classification (ReQuest/LA-classification) to assess complete remission of GORD.

A strategy for the assessment of QoL in patients with upper gastrointestinal symptoms is presented here. The QoL evaluation was based on a battery of questionnaires, covering both general and specific aspects of life. General well-being was evaluated with the Psychological General Well-being Index (PGWB), and subjective symptoms with two specific questionnaires, the Gastrointestinal Symptom Rating Scale (GSRS) and the Ulcus Esophagitis Subjective Symptoms Scale (UESS). This new strategy was applied clinically in a study including 146 outpatients with suspected peptic ulcer. Initially, the patients reported a low degree of general well-being as evaluated with the PGWB, but the values returned to those found in normal populations within 4 weeks.

Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis

Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis .

A total of 303 out of 522 (58%) clinically asymptomatic joints showed positive findings in GSUS and 53 out of 522 (10%) showed positive findings in PDUS. FOI displayed positive findings in 864 out of 1110 (78%) joints and in 473 out of 615 (77%) clinically asymptomatic joints. every 2 weeks was recommended for a further clinical Phase I study. ReQuest is a highly reliable, valid and responsive self-assessment tool for evaluating treatment response in patients with erosive GERD, and can be applied daily.

There is growing interest in measuring quality of life (QoL) in medicine. Together with objective variables such as healing rate, as recorded with endoscopy, this is believed to give a better basis for evaluation of treatment regimens in patients with upper gastrointestinal diseases.

Follow-up study conducted from October 1997 through October 1999 of a prospective randomized trial of medical and surgical antireflux treatments in patients with complicated GERD. Mean (median) duration of follow-up was 10.6 years (7.3 years) for medical patients and 9.1 years (6.3 years) for surgical patients. Although frequent vomiting reflexes during esophagogastroduodenoscopy (EGD) causes suffering in patients, very few studies have investigated the characteristics of subjects who frequently develop vomiting reflexes. This study examined the incidence of the vomiting reflex and related factors, especially upper gastrointestinal symptoms, among individuals undergoing transoral EGD. The differential diagnosis of Behçet’s syndrome or Crohn’s disease can be extremely difficult.

Three patients were treated at each dose level. In each group, at least eight injections (one injection/week) were intended.

FOI was compared with GSUS and PDUS findings of the clinically dominant hand in 962 joints. Four hundred and fifty-three joints were positive in GSUS, 148 in PDUS and 136 in GSUS and PDUS (including tenosynovitis).

gerd bahner

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